2nd video: Immune recognition and the danger theory – setting the context for HMGB1

Here is a new video-insight by Professor Marco E. Bianchi, Co-founder and Part-owner of HMGBiotech.
These video-insights will offer concise, focused segments from Prof. Bianchi’s lecture, each exploring a specific aspect of HMGB1 biology.

This second video provides essential background on how the immune system detects threats through Pattern-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs).

Prof. Bianchi introduces the Danger Theory, explaining how dendritic cells recognize microbial components via Toll-like receptors, triggering both innate and adaptive immune responses.
This immunological framework is crucial to understanding HMGB1’s extracellular activity—not as a pathogen-derived molecule, but as a self-derived signal of tissue damage that activates the immune system in a manner parallel to PAMPs.

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