Chemoresistance in small cell lung cancer
Emerging evidence identifies HMGB1 as a critical regulator of chemoresistance in small cell lung cancer (SCLC).
Chemoresistance in small cell lung cancer Read More »
News and events
Tumor cell migration
A study reveals that highly metastatic cancer cells possessing a functional Trx/TrxR axis respond robustly to the CXCL12/HMGB1 heterocomplex, exhibiting enhanced directional migration and invasiveness through CXCR4 activation.
Tumor cell migration Read More »
Video-insight | We can detect the HMGB1-CXCL12 complex in injured muscle and target it
The HMGB1–CXCL12 complex forms in injured muscle and can be detected by hybridization assay, while blocking HMGB1 with antibodies or glycyrrhizin effectively prevents the recruitment of inflammatory cells.
Video-insight | We can detect the HMGB1-CXCL12 complex in injured muscle and target it Read More »
Ischemic Stroke and neuroinflammation
In the acute ischemic phase, HMGB1 protein contributes to thromboinflammation, blood–brain barrier disruption, and immune cell activation, amplifying tissue injury.
Ischemic Stroke and neuroinflammation Read More »
Video-insight | NMR shows that HMGB1 and CXCL12 form a complex
NMR analysis revealed that HMGB1 and CXCL12 form a labile complex, primarily through HMGB1’s Box A, and in muscle injury this complex correlates with HMGB1 translocation from nuclei to cytoplasm and its active release to recruit inflammatory cells.
Video-insight | NMR shows that HMGB1 and CXCL12 form a complex Read More »
Progression of acute Liver inflammation
Recent findings provide mechanistic clarity, positioning Selenoprotein O (SelO) as a negative regulator of HMGB1-driven inflammation and ROS-dependent neutrophil extracellular trap (NET) formation.
Progression of acute Liver inflammation Read More »
Video-insight | How do cells migrate toward HMGB1?
Cell migration toward HMGB1 depends on the chemokine CXCL12 and its receptor CXCR4, as HMGB1 and CXCL12 act synergistically to induce chemoattraction even at non-active concentrations individually.
Video-insight | How do cells migrate toward HMGB1? Read More »
Osseointegration under diabetic conditions
We are glad to announce an interesting paper from Prof Claudia Biguetti, about a study in which has been used 3S-HMGB1, LPS-Free (HM-130) produced by HMGBiotech.
Osseointegration under diabetic conditions Read More »
Video-insight | Extracellular HMGB1 recruits and activates inflammatory cells
Under conditions of stress or tissue damage such as ischemia-reperfusion, cells actively secrete HMGB1, which serves as a key extracellular signal recruiting and activating inflammatory cells across multiple organs.
Video-insight | Extracellular HMGB1 recruits and activates inflammatory cells Read More »
