A key DAMP in infection-related cognitive impairment
Once released from stressed or damaged cells, HMGB1 acts as a DAMP and amplifies innate immune signaling.
A key DAMP in infection-related cognitive impairment Read More »
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Neuroinflammation in autoimmune thyroiditis
Emerging evidence points to HMGB1 as a critical molecular link between peripheral thyroid autoimmunity and neuroinflammation.
Neuroinflammation in autoimmune thyroiditis Read More »
Atrial fibrillation and prognosis in heart failure
A newly published study highlights the potential of HMGB1 as a clinically relevant biomarker in heart failure with preserved ejection fraction.
Atrial fibrillation and prognosis in heart failure Read More »
Inflammation in bacterial meningitis
A recent retrospective cohort study highlights the evolving role of High Mobility Group Box 1 (HMGB1) in pediatric bacterial meningitis (BM).
Inflammation in bacterial meningitis Read More »
Chemoresistance in small cell lung cancer
Emerging evidence identifies HMGB1 as a critical regulator of chemoresistance in small cell lung cancer (SCLC).
Chemoresistance in small cell lung cancer Read More »
Tumor cell migration
A study reveals that highly metastatic cancer cells possessing a functional Trx/TrxR axis respond robustly to the CXCL12/HMGB1 heterocomplex, exhibiting enhanced directional migration and invasiveness through CXCR4 activation.
Tumor cell migration Read More »
Video-insight | We can detect the HMGB1-CXCL12 complex in injured muscle and target it
The HMGB1–CXCL12 complex forms in injured muscle and can be detected by hybridization assay, while blocking HMGB1 with antibodies or glycyrrhizin effectively prevents the recruitment of inflammatory cells.
Video-insight | We can detect the HMGB1-CXCL12 complex in injured muscle and target it Read More »
Ischemic Stroke and neuroinflammation
In the acute ischemic phase, HMGB1 protein contributes to thromboinflammation, blood–brain barrier disruption, and immune cell activation, amplifying tissue injury.
Ischemic Stroke and neuroinflammation Read More »
Video-insight | NMR shows that HMGB1 and CXCL12 form a complex
NMR analysis revealed that HMGB1 and CXCL12 form a labile complex, primarily through HMGB1’s Box A, and in muscle injury this complex correlates with HMGB1 translocation from nuclei to cytoplasm and its active release to recruit inflammatory cells.
Video-insight | NMR shows that HMGB1 and CXCL12 form a complex Read More »
