Video-insight | We found that HMGB1 is a DAMP
HMGB1, a highly conserved nuclear protein, acts as a key DAMP that triggers strong immune responses across species.
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Video-insight | Polly Matzinger’s “Danger Theory”
Polly Matzinger’s Danger Theory: the immune system reacts to antigens only when linked to danger, not in calm conditions.
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Video-insight | Cell Death Originates Damage-Associated Molecular Patterns
When injured cells release DAMPs, the immune system detects danger without infection, triggering sterile inflammation.
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