Video-insight | Polly Matzinger’s “Danger Theory”
Polly Matzinger’s Danger Theory: the immune system reacts to antigens only when linked to danger, not in calm conditions.
Video-insight | Polly Matzinger’s “Danger Theory” Read More »
News and events
HMGB1’s role in age-related heart failure
On the occasion of World Heart Day, a recent study spotlights a critical molecular pathway linking cardiac aging, heart failure, and inflammation: the HMGB1–SNX3 axis.
HMGB1’s role in age-related heart failure Read More »
HMGB1’s multiple functions driven by intrinsic disorder and fuzzy interactions
We are pleased to announce the publication of a new scientific insight by Professor Marco E. Bianchi, Co-founder and Part-owner of HMGBiotech, regarding the Intrinsic disorder and Fuzzy interactions drive multiple functions of HMGB1.
HMGB1’s multiple functions driven by intrinsic disorder and fuzzy interactions Read More »
Video-insight | Cell Death Originates Damage-Associated Molecular Patterns
When injured cells release DAMPs, the immune system detects danger without infection, triggering sterile inflammation.
Video-insight | Cell Death Originates Damage-Associated Molecular Patterns Read More »
Video-insight | The background: PAMPS, DAMPs and Danger Theory
The Danger Theory explains how our immune system detects pathogens via PAMPs and trigers responses through dendritic cells
Video-insight | The background: PAMPS, DAMPs and Danger Theory Read More »
HMGB1 in Neonatal Encephalopathy: a predictive biomarker for early risk stratification
A recent study highlights the prognostic value of serum High-Mobility Group Box 1 (HMGB1) in neonates with neonatal encephalopathy (NE), providing new insights into early risk stratification in this vulnerable population.
HMGB1 in Neonatal Encephalopathy: a predictive biomarker for early risk stratification Read More »
World Hepatitis Day: HMGB1 as a central mediator in liver disease pathogenesis
In models of acute liver injury (ALI), such as acetaminophen overdose, HMGB1 drives immune cell infiltration and cytokine production through the HMGB1–TLR4 pathway.
World Hepatitis Day: HMGB1 as a central mediator in liver disease pathogenesis Read More »
Video-Insight | HMGB1 is a nuclear protein and a diffusible stress signal – with Prof. Marco E. Bianchi
In occasion of HMGBiotech’s 20th Anniversary we are pleased to launch a new video-insight series featuring selected excerpts delivered by Professor Marco E. Bianchi.
HMGB1 and oral squamous cell carcinoma: focus for World Head and Neck Cancer Day
A recent study underscores that HMGB1 is significantly overexpressed in OSCC tissues and cell lines and is strongly associated with metastasis and poor prognosis.
HMGB1 and oral squamous cell carcinoma: focus for World Head and Neck Cancer Day Read More »
