Video-insight | HMGB1 from Necrotic Cells Boosts the Poor Immunogenicity of “Self” Apoptotic Lymphoma Cells
Experiments showed HMGB1 activates immunity: with it, tumors are rejected and weak antigens trigger strong antibody responses.
News and events
BoxAB: a tailored tool to dissect HMGB1 function in aging and inflammation
Aging continues to be a central theme in biomedical research, and HMGB1 has emerged as a critical player in the chronic, low-grade inflammation that underpins many age-related conditions.
BoxAB: a tailored tool to dissect HMGB1 function in aging and inflammation Read More »
Video-insight | HMGB1 is retained by cells that die apoptotically but released by cells that die in any other way
HMGB1 is retained in apoptosis but released in necrosis and other cell deaths, signaling the immune system that danger is present.
HMGB1 in Pancreatic Cancer: dual regulator of tumor progression and immune activation
Recent findings highlight the multifaceted involvement of HMGB1 (High Mobility Group Box 1) in both tumor-promoting mechanisms and immune modulation, making it a critical molecular node in pancreatic cancer biology.
HMGB1 in Pancreatic Cancer: dual regulator of tumor progression and immune activation Read More »
Video-insight | We found that HMGB1 is a DAMP
HMGB1, a highly conserved nuclear protein, acts as a key DAMP that triggers strong immune responses across species.
Video-insight | We found that HMGB1 is a DAMP Read More »
HMGB1 as a promising clinical biomarker in cholangiocarcinoma (CCA)
A recent study has provided new insights into HMGB1 expression patterns in CCA by integrating transcriptomic, immunohistochemical, and serological data.
HMGB1 as a promising clinical biomarker in cholangiocarcinoma (CCA) Read More »
Video-insight | Polly Matzinger’s “Danger Theory”
Polly Matzinger’s Danger Theory: the immune system reacts to antigens only when linked to danger, not in calm conditions.
Video-insight | Polly Matzinger’s “Danger Theory” Read More »
HMGB1’s role in age-related heart failure
On the occasion of World Heart Day, a recent study spotlights a critical molecular pathway linking cardiac aging, heart failure, and inflammation: the HMGB1–SNX3 axis.
HMGB1’s role in age-related heart failure Read More »
HMGB1’s multiple functions driven by intrinsic disorder and fuzzy interactions
We are pleased to announce the publication of a new scientific insight by Professor Marco E. Bianchi, Co-founder and Part-owner of HMGBiotech, regarding the Intrinsic disorder and Fuzzy interactions drive multiple functions of HMGB1.
HMGB1’s multiple functions driven by intrinsic disorder and fuzzy interactions Read More »
