HMGBiotech specializes in the production of LPS-free proteins. LPS (Bacterial endotoxin lipopolysaccharide) is a powerful inducer of the immune system and can introduce undesirable variables and limitations in certain experimental setups.
News and events
A recent paper published on Molecular Medicine journal highlights how High Mobility Group Box 1 (HMGB1) and other biomolecules influence fatigue in patients with Crohn’s diseases.
HMGBiotech Srl has taken part to a study, published in June, in which are discovered CXCL12 as the first fuzzy chemokines heterocomplex reported so far and the unexpected role of the acidic intrinsically disordered region (IDR), in HMGB1●CXCL12 heterocomplex formation.
A new research, in which HMGBiotech Srl participated, has unmasked an unexpected player in the world of chemokine interactions: the acidic intrinsically disordered region (IDR).
HMGBiotech participated in a recent study in which, through an integrative structural approach, molecular details of HMGB1●CXCL12 heterocomplex formation were unveiled.
The interaction between SDF-1 chemokine protein (CXCL12) and HMGB1 generates an heterocomplex which plays an unique role in homeostatic regulation.
Disulfide-HMGB1 is a recombinant protein that can induce cytokine and chemokine production in monocytes and other inflammatory cells.
Deeplearning language model applied to design proteins sequence