Even after 20 Years, HMGB1 continues to surprise us. A groundbreaking international study has unveiled a critical new role for HMGB1 that could redefine how we think about the biology of aging. Blood protein HMGB1 could be spreading aging throughout the body, acting as a systemic messenger of senescence.
A team of researchers led by South Korean scientists has demonstrated that ReHMGB1-fully reduced HMGB1, is not only a multifunctional mediator of inflammation and tissue repair but also a potent inducer of aging-related cellular phenotypes.
ReHMGB1 can travel through the bloodstream to distant tissues, where it triggers cellular senescence.
Fully reduced HMGB1 emerges as a pro-geronic factor in aging
This finding is particularly striking because it establishes extracellular fully reduced HMGB1, as a redox-dependent pro-geronic factor, capable of converting local senescent signals into systemic aging.
In contrast, the oxidized disulfide form of HMGB1 did not produce the same effects, underscoring the unique biology of the fully reduced redox state. This is the first evidence that ReHMGB1 alone drives systemic senescence propagation.
Perhaps most importantly, the study offers hope for therapeutic intervention: blocking extracellular HMGB1 with neutralizing antibodies effectively suppressed senescence, reduced systemic inflammation, and promoted tissue regeneration in a muscle injury model in middle-aged mice. This suggests that HMGB1-targeting strategies could represent a promising avenue for mitigating age-related pathologies.
ReHMGB1 for your research purposes
At HMGBiotech, we have supported countless researchers studying HMGB1’s diverse functions in immunity, inflammation, regeneration—and now, aging. Our fully reduced HMGB1 (ReHMGB1) is available as a high-purity reagent produced in E.coli, free of endotoxins (LPS-free), and without tags or extraneous amino acids.
It has been validated in chemotaxis assays and is ready to accelerate your investigations into HMGB1’s role in senescence and beyond.
Discover fully reduced HMGB1 (ReHMGB1), LPS-Free: https://www.hmgbiotech.eu/product/fully-reduced-hmgb1-500-%c2%b5g-hm-114/
Contact us for your pre-sales questions about ReHMGB1
Read the full article about the study
