To celebrate the 50th anniversary of the discovery of High Mobility Group Box 1 (HMGB1), it is important to underline its multifaceted roles in cellular biology and disease pathology. HMGB1, initially identified in 1973 as a mere structural protein in chromatin, has then emerged as a critical regulator in a lot of biological processes.
HMGB1 is involved in several mechanisms like nuclear DNA repair, immune responses in cytosol, and extracellularly with immunoreceptors. It’s also a key sensor of cellular stress in various pathologies including infectious diseases, autoimmunity, and cancer. This understanding opens new therapeutic possibilities in disease treatment.
Beyond these roles, HMGB1 acts as a broad sensor of cellular stress balancing cell death and survival. It has a crucial role in maintaining cellular homeostasis and tissue integrity. It is a key mediator secreted by immune cells, implicated in different pathological conditions such as infectious diseases, ischaemia-reperfusion injury, autoimmunity, cardiovascular and neurodegenerative disorders, metabolic dysfunctions, and cancer.
Understanding the signaling mechanisms and cellular functions of HMGB1 opens new therapeutic approaches. Modulating its release and its biological activities address to new therapeutic strategies in differents pathologies.
HMGBiotech can provide comprehensive information to facilitate informed decision-making for research involving HMGB1.
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Read the full article about the study: https://pubmed.ncbi.nlm.nih.gov/37322174/