Drug-resistant epilepsy: the key role of HMGB1 as a biomarker

High-mobility group box 1 (HMGB1) is increasingly recognized as a critical player in epilepsy pathogenesis and progression, as demonstrated by studies focusing on its role as a biomarker in the disease.

Patients with drug-resistant epilepsy show higher levels of blood HMGB1 compared to healthy controls or drug-resistant patients. These findings are crucial because there are no sensitive and specific biomarkers of drug-resistant epilepsy.
Other studies found that high levels of HMGB1 in epilepsy are linked to drug resistance mechanism.
HMGB1 can act as a clinical biomarker, distinguishing between drug-resistant and drug-responsive epilepsy with high specificity and selectivity.
Future researches most probably will elucidate the relationship between HMGB1 levels and epilepsy, with the potential for developing new targets and effective treatments.

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