In occasion of HMGBiotech’s 20th Anniversary we are pleased to launch a new video-insight series featuring selected excerpts from the seminar “High Mobility Group Box 1 (HMGB1) and sterile inflammation: From tissue damage & regeneration to cancer immunity,” delivered by Professor Marco E. Bianchi, Co-founder and Part-owner of HMGBiotech.
These video will offer concise, focused segments from Prof. Bianchi’s lecture, each exploring a specific aspect of HMGB1 biology.
1st Video: From nuclear protein to immune signal – the HMGB1 journey
In this opening video, Prof. Bianchi traces the evolution of HMGB1 from its initial discovery as a nuclear DNA-binding protein to its unexpected role as a Damage-Associated Molecular Pattern (DAMP). He outlines key breakthroughs, including its secretion by immune cells during sepsis, the discovery of its distinct redox-dependent functions, and its surprising involvement in tissue regeneration and cancer immune surveillance.
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